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Thomas C Chen Selected Research

Melanoma (Melanoma, Malignant)

1/2023Enhanced brain entry of checkpoint-inhibitory therapeutic antibodies facilitated by intraarterial NEO100 in mouse models of brain-localized malignancies.
12/2018NEO412: A temozolomide analog with transdermal activity in melanoma in vitro and in vivo.
9/2018Rare Stochastic Expression of O6-Methylguanine- DNA Methyltransferase (MGMT) in MGMT-Negative Melanoma Cells Determines Immediate Emergence of Drug-Resistant Populations upon Treatment with Temozolomide In Vitro and In Vivo.
3/2015A novel temozolomide analog, NEO212, with enhanced activity against MGMT-positive melanoma in vitro and in vivo.

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Thomas C Chen Research Topics

Disease

92Neoplasms (Cancer)
02/2024 - 01/2003
47Glioma (Gliomas)
01/2021 - 05/2002
35Glioblastoma (Glioblastoma Multiforme)
12/2023 - 01/2003
22Brain Neoplasms (Brain Tumor)
12/2023 - 04/2005
6Breast Neoplasms (Breast Cancer)
12/2021 - 09/2009
6Meningioma (Meningiomas)
04/2020 - 01/2007
4Nasopharyngeal Carcinoma
02/2024 - 08/2015
4Melanoma (Melanoma, Malignant)
01/2023 - 03/2015
4Neoplasm Metastasis (Metastasis)
10/2021 - 09/2010
4Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
06/2019 - 03/2016
4Multiple Myeloma
03/2019 - 12/2005
3Hypoxia (Hypoxemia)
10/2020 - 01/2013
2Lymphoma (Lymphomas)
12/2023 - 11/2006
2Spinal Cord Injuries (Spinal Cord Injury)
11/2023 - 01/2020
2Cicatrix (Scar)
01/2023 - 01/2020
2Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
12/2022 - 07/2021
2Infections
01/2022 - 12/2005
2Necrosis
01/2017 - 09/2014
2Triple Negative Breast Neoplasms
03/2016 - 01/2013
2Vascular Diseases (Vascular Disease)
05/2014 - 01/2014
2Carcinogenesis
01/2013 - 05/2011
2Hydrocephalus (Hydrocephaly)
09/2010 - 11/2006

Drug/Important Bio-Agent (IBA)

35Temozolomide (Temodar)FDA LinkGeneric
02/2024 - 04/2006
31perillyl alcoholIBA
02/2024 - 11/2012
14NEO212IBA
02/2024 - 08/2014
11Celecoxib (Celebrex)FDA Link
12/2012 - 01/2004
9DNA (Deoxyribonucleic Acid)IBA
12/2022 - 03/2011
7Alkylating AgentsIBA
12/2022 - 03/2011
7Proteins (Proteins, Gene)FDA Link
01/2020 - 01/2007
7Endoplasmic Reticulum Chaperone BiPIBA
01/2013 - 04/2007
7Cyclooxygenase 2 Inhibitors (COX-2 Inhibitors)IBA
12/2012 - 01/2004
6MethyltransferasesIBA
12/2023 - 08/2014
6Bevacizumab (Avastin)FDA Link
01/2022 - 09/2014
6IntegrinsIBA
11/2020 - 01/2003
6VaccinesIBA
08/2018 - 03/2008
6Irinotecan (Camptosar)FDA LinkGeneric
03/2015 - 05/2003
5Chloroquine (Aralen)FDA LinkGeneric
12/2023 - 12/2012
5DisintegrinsIBA
11/2020 - 01/2003
5Antineoplastic Agents (Antineoplastics)IBA
11/2020 - 07/2005
5Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
01/2019 - 04/2005
5Nelfinavir (Viracept)FDA Link
12/2012 - 01/2007
52,5-dimethylcelecoxibIBA
12/2012 - 04/2007
4Snake Venoms (Snake Venom)IBA
11/2020 - 01/2003
4Bortezomib (Velcade)FDA Link
03/2019 - 02/2008
4Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
10/2016 - 04/2005
4SurvivinIBA
08/2008 - 05/2006
4contortrostatinIBA
09/2005 - 01/2003
3Phosphotransferases (Kinase)IBA
12/2023 - 11/2002
3RolipramIBA
12/2023 - 05/2002
3Trastuzumab (Herceptin)FDA Link
12/2021 - 09/2009
3ProdrugsIBA
02/2020 - 01/2003
3Proteasome InhibitorsIBA
03/2019 - 06/2009
3AntigensIBA
08/2018 - 01/2012
3Reactive Oxygen Species (Oxygen Radicals)IBA
03/2016 - 01/2016
3Drug CombinationsIBA
12/2012 - 02/2008
3hypericinIBA
11/2011 - 05/2003
3epigallocatechin gallate (epigallocatechin-3-gallate)IBA
03/2011 - 10/2007
3Topoisomerase I InhibitorsIBA
03/2011 - 05/2003
3Endothelin-1 (Endothelin 1)IBA
03/2010 - 04/2005
3Cyclooxygenase 2 (Cyclooxygenase-2)IBA
09/2009 - 05/2005
3Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA
02/2008 - 01/2004
3Small Interfering RNA (siRNA)IBA
02/2008 - 04/2007
3TamoxifenFDA LinkGeneric
04/2006 - 11/2002
2AntibodiesIBA
01/2023 - 01/2003
2A-Form DNA (A-DNA)IBA
12/2022 - 11/2018
2O-(6)-methylguanineIBA
12/2022 - 01/2020
2Monoterpenes (Monoterpenoids)IBA
08/2022 - 11/2012
2RNA (Ribonucleic Acid)IBA
01/2021 - 01/2020
2Cytosine DeaminaseIBA
02/2020 - 01/2003
2Flucytosine (Ancobon)FDA Link
02/2020 - 01/2003
2bromopyruvateIBA
11/2018 - 01/2017
2VenomsIBA
11/2018 - 01/2005
2GuanineIBA
09/2018 - 08/2014
2Neoplasm Antigens (Tumor Antigens)IBA
08/2018 - 03/2008
2Adenosine Triphosphate (ATP)IBA
01/2017 - 10/2007
2Neurotransmitter Agents (Neurotransmitter)IBA
12/2016 - 03/2016
2AutoantigensIBA
05/2015 - 01/2012
2Antimalarials (Antimalarial Agents)IBA
03/2015 - 12/2012
2Mefloquine (Lariam)FDA LinkGeneric
03/2015 - 12/2012
2quinolineIBA
03/2015 - 12/2012
2MicroRNAs (MicroRNA)IBA
05/2014 - 01/2014
2Biomarkers (Surrogate Marker)IBA
01/2013 - 08/2008
2HIV Protease InhibitorsIBA
12/2012 - 09/2009
2Cytotoxins (Cytolysins)IBA
11/2012 - 03/2011
2resiquimodIBA
05/2012 - 01/2012
2Matrix Metalloproteinases (MMPs)IBA
05/2011 - 01/2003
2TeaIBA
03/2011 - 06/2009
2Interleukin-8 (Interleukin 8)IBA
03/2010 - 11/2005
2Proteasome Endopeptidase Complex (Proteasome)IBA
06/2009 - 11/2007
2Caspase 7IBA
06/2009 - 10/2007
2Green Fluorescent ProteinsIBA
04/2006 - 12/2005

Therapy/Procedure

39Therapeutics
12/2023 - 05/2003
20Drug Therapy (Chemotherapy)
11/2021 - 09/2005
7Radiotherapy
01/2020 - 11/2006
5Intranasal Administration
08/2022 - 11/2012
2Salvage Therapy
11/2021 - 11/2011
2Brachytherapy
11/2021 - 11/2018
2Immunotherapy
08/2018 - 05/2012
2Chemoradiotherapy
04/2018 - 12/2015
2Ventriculoperitoneal Shunt
09/2010 - 11/2006